Related Experiment Video
Updated: Jul 6, 2026

Isolation of Human Primary Valve Cells for In vitro Disease Modeling
Published on: April 16, 2021
Pathology of the diffuse variant of supravalvar aortic stenosis
P Vaideeswar1, V Shankar, J R Deshpande
1Department of Pathology, Cardiovascular and Thoracic Division, Seth G.S. Medical College and K.E.M. Hospital, Parel, Mumbai 400 012, India. pradeep@jpgm.com
Abstract:
Supravalvar aortic stenosis is a rare congenital heart anomaly, producing left ventricular outflow tract obstruction. Of the two anatomic variants that have been described, diffuse type is the rarest. We report five such cases in children between two months and nine years of age. None had features of Williams syndrome. The entire aorta was involved in three cases, with abdominal aortic coarctation in two cases. Stenosis was mainly due to involvement of the media, which showed smooth muscle hypertrophy, abnormal elastic fibers, and mild collagenization. Predominant intimal change was seen in one case. Pulmonary, coronary, arch, renal, and common iliac arteries were also involved.
Related Concept Videos
Mitral Valve Prolapse I: Introduction
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests
Aortic Regurgitation I: Introduction
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Aneurysm I: Introduction

