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Published on: October 12, 2017

LDL-cholesterol reduction is not associated with deterioration of cellular integrity after myocardial infarction - a

Izabela Jarosz1, Michal Mazur1, Joanna Popiolek-Kalisz2

  • 1Department of Clinical Dietetics, Medical University of Lublin, Lublin, Poland; Doctoral School, Medical University of Lublin, Lublin, Poland.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|July 30, 2026
PubMed

Insights

Intensive low-density lipoprotein cholesterol (LDL-C) lowering after myocardial infarction did not harm cell membrane integrity, as measured by phase angle at 50 kHz (PhA50). This finding provides reassurance for aggressive lipid-lowering therapies in cardiac patients.

Area of Science:

  • Cardiology
  • Biophysics

Background:

  • Intensive low-density lipoprotein cholesterol (LDL-C) reduction is crucial for secondary prevention post-myocardial infarction.
  • Concerns exist about potential adverse effects of very low LDL-C on cellular membrane integrity.
  • Phase angle at 50 kHz (PhA50) from bioelectrical impedance analysis (BIA) reflects cell membrane properties.

Purpose of the Study:

  • To assess the association between LDL-C reduction and changes in PhA50 after myocardial infarction.
  • To investigate the impact of intensive lipid-lowering on cellular integrity markers.

Main Methods:

  • Longitudinal analysis of 45 patients post-myocardial infarction undergoing cardiac rehabilitation.
  • Assessment of lipid profile, BMI, and PhA50 at rehabilitation entry and completion.
  • Correlation and regression analyses to examine the relationship between LDL-C reduction and PhA50 change.

Main Results:

  • Significant LDL-C reduction (approx. 60.5%) was observed.
  • PhA50 remained stable throughout the follow-up period (p=0.332).
  • No correlation or association was found between LDL-C reduction and PhA50 change; age was an inverse predictor of PhA50 change.

Conclusions:

  • Substantial LDL-C reduction post-myocardial infarction is not linked to PhA50 deterioration.
  • This study offers physiological reassurance for cellular integrity during intensive lipid-lowering therapies.
Abstract

Keywords:
Cardiovascular diseaseDyslipidemiaLipid disordersMalnutritionPhase angle

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