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Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity

C F Fletcher1, A Tottene, V A Lennon

  • 1Mouse Cancer Genetics Program, National Cancer Institute-FCRDC, Frederick, Maryland 21702, USA. Fletcher@gnf.org

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|May 10, 2001
PubMed
Abstract

No abstract available in PubMed .

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Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...

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