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Updated: Jul 22, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
The use of becaplermin (rhPDGF-BB) gel for chronic nonhealing ulcers. A retrospective analysis
V J Mandracchia1, S M Sanders, J A Frerichs
1Foot and Ankle Clinics, Broadlawns Medical Center, Des Moines, Iowa, USA.
Abstract:
Chronic, nonhealing wounds have plagued health care practitioners for decades. New research and technology have allowed the wound healing process to be understood at a cellular and molecular level, including the vital role of growth factors. This article discusses the effects of platelet-derived growth factor-BB (PDGF-BB) on the wound healing process, emphasizing the inflammatory stage of wound healing and principles of wound care. Preclinical and clinical studies evaluating recombinant human PDGF-BB (rhPDGF-BB) (becaplermin gel) also are discussed. Lastly, the results of a retrospective analysis evaluating the use of rhPDGF-BB at Broadlawns Medical Center (Des Moines, IA) are presented.

