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Childhood optic atrophy.

A V Mudgil1, M X Repka

  • 1The Wilmer Ophthalmological Institute at Johns Hopkins Hospital, Division of Paediatric Ophthalmology and Strabismus, Baltimore, Maryland 21287-9028, USA. vmudgil@jhmi.edu

Clinical & Experimental Ophthalmology
|May 10, 2001
PubMed
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Complications from premature birth and hydrocephalus are leading causes of optic nerve atrophy in children under 10. Improved survival rates for premature infants contribute to this trend.

Area of Science:

  • Ophthalmology
  • Pediatric Neurology
  • Neonatology

Background:

  • Optic nerve atrophy (ONA) in children is a significant cause of vision loss.
  • Understanding the evolving etiology of ONA is crucial for early diagnosis and intervention.

Purpose of the Study:

  • To identify the common causes and their incidence in children under 10 years old diagnosed with optic nerve atrophy.
  • To compare current etiological trends with historical data.

Main Methods:

  • Retrospective review of medical records for children diagnosed with optic atrophy between 1987 and 1997.
  • Inclusion criteria: patients under 10 years old at diagnosis.

Main Results:

  • 272 children were identified with optic atrophy.

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  • Most frequent causes: prematurity complications (16%), tumors (15%), and hydrocephalus (10%).
  • Perinatal factors or adverse in utero events accounted for 42% of cases.

    • Conclusions:

    • Prematurity and hydrocephalus have emerged as significant causes of childhood optic atrophy.
    • Improved survival of extremely low birth weight infants likely contributes to this observed trend.