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Selectins in normal pregnancy, pre-eclampsia and missed abortus
1Department of Gynecology, SU, Konya, Turkey.
Insights
Selectin levels, including P and L selectins, are elevated in pre-eclampsia and missed abortion, suggesting they are markers of endothelial injury, not causes.
Area of Science:
- Obstetrics and Gynecology
- Immunology
- Vascular Biology
Background:
- Selectins are implicated in endothelial cell injury.
- Elevated selectin levels are observed in pre-eclampsia patients.
Purpose of the Study:
- To investigate P, E, and L selectin levels in normal pregnancy, pre-eclampsia, and missed abortion.
- To determine if selectins are markers or causes of endothelial injury in these conditions.
Main Methods:
- Plasma levels of P, E, and L selectins were measured.
- Comparison between healthy controls, normal pregnancy, pre-eclampsia, and missed abortion groups.
Main Results:
- Plasma P and L selectins were higher in normal pregnancy and pre-eclampsia than controls.
- E selectin levels did not differ between these groups.
- P selectin was higher in pre-eclampsia than normal pregnancy.
- All selectins were higher in missed abortion than controls.
- L selectin was higher in pre-eclampsia and missed abortion than normal pregnancy.
Conclusions:
- Selectin levels are increased in pre-eclampsia and missed abortion.
- Elevated selectins are likely a non-specific consequence of endothelial injury.
- Selectins may not be a direct cause in the pathogenesis of pre-eclampsia.
Abstract:
Selectins, are known to be increased in the serum of patients with pre-eclampsia, indicating that these molecules are possible markers of endothelial cell injury. In this study, we investigated P, E and L selectin levels in normal pregnancy, pre-eclampsia, and missed abortus. Plasma P and L selectins levels were significantly higher in normal pregnancy and pre-eclampsia than healthy controls; but plasma concentrations of E selectins were not different between these groups. Plasma P selectin was significantly higher in pre-eclampsia than normal pregnancy. Plasma concentrations of all selectins were significantly higher in missed abortus than healthy control. L selectin levels were higher in pre-eclampsia and missed abortus than normal pregnancy. We found the levels of selectins were increased in pre-eclampsia and missed abortus. Although selectins were suspected to play a role in the pathogenesis of pre-eclampsia, in conjunction with previous studies, we thought that elevated selectin levels are a non-specific consequence of endothelial injury rather than being a cause.