Related Experiment Video

Updated: Aug 3, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Factor V Leiden mutation in postthrombotic and non-postthrombotic venous ulcers

J Hafner1, A Kühne, B Schär

  • 1Department of Dermatology, University Hospital of Zurich, CH-8091 Zurich, Switzerland. jhafner@derm.unizh.ch

Archives of Dermatology
|May 18, 2001
PubMed

Insights

The factor V Leiden mutation is highly prevalent in patients with postthrombotic venous ulcers, with a 38% occurrence. Even non-postthrombotic ulcers show a moderately elevated prevalence, suggesting a potential genetic link in venous ulceration.

Area of Science:

  • Vascular Medicine
  • Genetics
  • Dermatology

Background:

  • Venous ulcers are a significant clinical challenge.
  • The role of genetic factors, such as the factor V Leiden mutation, in venous ulcer development is not fully understood.
  • Postthrombotic syndrome is a common complication following deep vein thrombosis and a frequent cause of venous ulcers.

Purpose of the Study:

  • To investigate the prevalence of the factor V Leiden mutation in patients suffering from postthrombotic and non-postthrombotic venous ulcers.
  • To compare the frequency of the factor V Leiden mutation between these two groups of patients.

Main Methods:

  • A case-control study was conducted.
  • Seventy-three patients with venous ulcers were compared to 45 age- and sex-matched controls.
  • The study assessed the frequency of postthrombotic and non-postthrombotic findings and the prevalence of the factor V Leiden mutation in venous ulcer subgroups.

Main Results:

  • Postthrombotic syndrome accounted for 58% of the 73 venous ulcers studied.
  • The factor V Leiden mutation prevalence was 38% in postthrombotic ulcers (OR, 13.2; P<.001) and 16% in non-postthrombotic ulcers (OR, 3.2; P=.07).
  • A significantly higher prevalence of the factor V Leiden mutation was observed in patients with postthrombotic venous ulcers compared to non-postthrombotic ones.

Conclusions:

  • The factor V Leiden mutation is highly prevalent in patients with postthrombotic venous ulcers.
  • A moderately elevated prevalence of the factor V Leiden mutation was also noted in non-postthrombotic venous ulcers.
  • While genetic predisposition is evident, systematic screening for factor V Leiden mutation in venous ulcer patients is not currently recommended due to unestablished therapeutic consequences.
Abstract

More Related Videos

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography06:44

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Published on: April 13, 2018

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Related Concept Videos

Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...