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[In vitro evaluation of antileishmania activity of Artemisia herba alba Asso]

S Hatimi1, M Boudouma, M Bichichi

  • 1Laboratoire de microbiologie et de biologie moléculaire, département de biologie, Faculté des sciences Ben M'sik, Université Hassan II-Mohamedia, BP: 7955, Ben M'sik, Casablanca, Maroc. saida.hatimi@aventis.com

Bulletin De La Societe De Pathologie Exotique (1990)
|May 12, 2001
PubMed

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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...