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Updated: Aug 6, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
Structure-based design of non-peptide HIV protease inhibitors
1Department of Chemistry, University of Illinois at Chicago, IL 60607, USA. arunghos@uic.edu
Abstract:
A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.
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