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Updated: Aug 9, 2026

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
Published on: September 16, 2014
Coplanar recognition by a Rebek cleft is provided by cooperative structural effects involving a combination of
L R MacGillivray1, M M Siebke, J L Reid
1Department of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, USA.
Abstract:
Reaction of 2,7-di-tert-butyl-9,9-dimethyl-4,5-xanthenedicarboxylic acid (1), a Rebek cleft, with 1,2-trans-bis(2-pyridyl)ethylene (2) yields a three-component organic assembly, 2(1).2 (3), of nanoscale dimensions that is held together by 10 cooperative O-H.N, O-H.O, and C-H.O hydrogen bonds. The cleft adopts a planar conformation, by forming an intramolecular O-H.O hydrogen bond, which enables the host to recognize the guest in a coplanar orientation that facilitates the cooperativity displayed by the multiple forces.
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