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Anergy during pregnancy.

T D Jackson1, A P Murtha

  • 1Department of Maternal-Fetal Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

American Journal of Obstetrics and Gynecology
|May 12, 2001
PubMed
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Pregnant women do not show a higher prevalence of anergy compared to nonpregnant women. Anergy testing is likely unnecessary for pregnant women evaluated with the purified protein derivative of tuberculin skin test.

Area of Science:

  • Immunology
  • Obstetrics
  • Infectious Disease

Background:

  • Anergy, a state of immune unresponsiveness, can affect cell-mediated immunity.
  • Assessing anergy prevalence in pregnant populations is crucial for accurate diagnostic interpretation.

Purpose of the Study:

  • To investigate if pregnant women exhibit a higher prevalence of anergy than nonpregnant women.
  • To determine the necessity of anergy testing in pregnant individuals.

Main Methods:

  • Sixty human immunodeficiency virus-seronegative women (30 pregnant, 30 nonpregnant) were enrolled.
  • Skin tests were administered using purified protein derivative of tuberculin, Candida antigen, mumps antigen, and tetanus toxoid.
  • Data were analyzed using Fisher exact test and t test.

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Main Results:

  • Overall anergy prevalence was 10%, with three non-responsive women in each group.
  • Pregnant women showed significantly lower reactivity to tetanus toxoid compared to nonpregnant women (10% vs 40%; P <.02).

Conclusions:

  • Human immunodeficiency virus-seronegative pregnant women do not have a higher prevalence of anergy than nonpregnant controls.
  • Anergy skin testing is unlikely to be necessary for pregnant women undergoing purified protein derivative of tuberculin skin testing solely due to pregnancy.