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Updated: Jul 23, 2026

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
Towards a novel treatment strategy for acute pancreatitis. 2. Principles and potential practice
1Pancreato-Biliary Service, Manchester Royal Infirmary, Manchester, UK. jenny.parr@man.ac.uk
Abstract:
In part 1 it was argued that a 'free radical-mast cell' template for the aetiogenesis of acute pancreatitis accommodates the evidence, whereas the prevailing 'trypsin-cytokine' template does not. In this sequel I examine the ramifications of the new philosophy in relation to speedier diagnosis, prognostic aids and, above all, a programme of active treatment which - once validated in experimental studies - could be implemented by the first medical respondent.
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Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management
Chronic Pancreatitis II: Collaborative Care
Assessment:
Acute Pancreatitis I: Introduction
Acute Pancreatitis II: Pathophysiology
Chronic Pancreatitis II: Pathophysiology

