Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-box genes in development: from hydra to humans.

V E Papaioannou1

  • 1Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.

International Review of Cytology
|May 16, 2001
PubMed
Summary

The T-box gene family plays a crucial role in animal development. Research is uncovering their function as transcriptional regulators and their essential role in embryogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temperature multiscale entropy analysis: a promising marker for early prediction of mortality in septic patients.

Physiological measurement·2013
Same author

Early embryonic lethality in genetically engineered mice: diagnosis and phenotypic analysis.

Veterinary pathology·2011
Same author

The oocyte population is not renewed in transplanted or irradiated adult ovaries.

Human reproduction (Oxford, England)·2008
Same author

Effect of a policy for restriction of selected classes of antibiotics on antimicrobial drug cost and resistance.

Journal of chemotherapy (Florence, Italy)·2007
Same author

The McLaren effect--a personal view.

The International journal of developmental biology·2001
Same author

DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1.

Nature genetics·2001

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • The T-box gene family, identified recently, is vital for metazoan development.
  • Orthologs are found across diverse species, highlighting conserved functions.
  • T-box genes encode a DNA-binding motif crucial for their regulatory roles.

Purpose of the Study:

  • To explore the functions of T-box genes in development.
  • To identify downstream target genes regulated by T-box proteins.
  • To investigate the regulatory mechanisms governing T-box gene expression.

Main Methods:

  • Extensive gene screening and database searches.
  • Analysis of T-box gene orthologs in various species.
  • Characterization of T-box gene expression patterns during embryogenesis.

Main Results:

  • Several T-box gene subfamilies with conserved functions have been identified.
  • T-box proteins function as transcriptional regulators.
  • T-box gene expression is dynamic and tissue-specific during development.

Conclusions:

  • T-box genes are essential regulators of developmental processes.
  • Further research is needed to fully elucidate T-box gene targets and regulation.
  • Mutant animal phenotypes underscore the critical roles of T-box genes in development.

Related Experiment Videos