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Neurotrophic keratopathy.

N Pushker1, T Dada, R B Vajpayee

  • 1Dr. RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.

The CLAO Journal : Official Publication of the Contact Lens Association of Ophthalmologists, Inc
|May 16, 2001
PubMed
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Neurotrophic keratopathy, a corneal condition caused by trigeminal nerve damage, leads to progressive corneal changes and potential perforation. Early, aggressive treatment is crucial to prevent severe vision loss.

Area of Science:

  • Ophthalmology
  • Neurology
  • Corneal Disease

Background:

  • Neurotrophic keratopathy involves corneal and conjunctival degeneration due to impaired trigeminal nerve sensation.
  • Herpes virus infections are a frequent cause of reduced corneal sensation.

Purpose of the Study:

  • To comprehensively review neurotrophic keratopathy.
  • Encompasses causes, clinical presentation, disease progression, diagnostic methods, and therapeutic strategies.

Main Methods:

  • Literature review on neurotrophic keratopathy.

Main Results:

  • Corneal epithelium breakdown occurs even without external factors like infection or trauma.
  • Untreated, it can progress to stromal lysis and perforation.

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Conclusions:

  • Neurotrophic keratopathy requires aggressive management including lubricants, tarsorrhaphy, or bandage contact lenses.
  • Surgical interventions like cyanoacrylate glue, penetrating keratoplasty, or conjunctival flaps may be necessary for perforation.