Related Experiment Videos
Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series
K N Roy Chengappa1, J Levine, D Rathore
1Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213-2593, USA. chengappakn@msx.upmc.edu
Abstract:
Topiramate is an antiepileptic agent, which is being investigated as a mood-stabilizer. Three obese individuals with DSM-IV bipolar I disorder and type II diabetes mellitus received topiramate treatment in combination with antipsychotics and valproate or carbamazepine. In addition to improved mood stability, these individuals lost between 16 to 20.5% of their pre-topiramate body weight and also achieved significant glycemic control.