Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of utero-placental blood flow during prostaglandin F2alpha induced abortion.

M O Pulkkinen, Y Pitkanen, A Ojala

    Prostaglandins
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of simulated herbivory on tillering and reproduction in an annual ryegrass,Lolium remotum.

    Oecologia·2017
    Same author

    The Rosti sling: a new, minimally invasive, tension-free technique for the surgical treatment of female urinary incontinence-the first 217 patients.

    The Journal of urology·2004
    Same author

    Oral vinorelbine in combination with cisplatin: a novel active regimen in advanced non-small-cell lung cancer.

    Annals of oncology : official journal of the European Society for Medical Oncology·2003
    Same author

    CT lung densitometry in assessing intralobular air content. An experimental and clinical study.

    Acta radiologica (Stockholm, Sweden : 1987)·2000
    Same author

    DNA flow cytometry in surgically treated lung cancer--prognostic significance.

    Scandinavian cardiovascular journal : SCJ·1999
    Same author

    Quality control in health care: an experiment in radiotherapy planning for breast cancer patients after mastectomy.

    International journal of radiation oncology, biology, physics·1999

    Prostaglandin F2alpha (PGF2alpha) use for pregnancy termination significantly reduced utero-placental blood flow early on. This early decrease in blood flow is a key mechanism in PGF2alpha

    Area of Science:

    • Reproductive Medicine
    • Pharmacology
    • Obstetrics

    Background:

    • Midtrimester pregnancy termination often involves pharmacologic agents.
    • Understanding the mechanisms of prostaglandin action is crucial for safe clinical application.

    Purpose of the Study:

    • To investigate the effect of prostaglandin F2alpha (PGF2alpha) on utero-placental blood flow during midtrimester pregnancy termination.
    • To determine if decreased utero-placental blood flow is an early event in PGF2alpha-induced pregnancy termination.

    Main Methods:

    • Extraovular injection of 10 mg prostaglandin F2alpha (PGF2alpha) in 6 patients.
    • Measurement of utero-placental blood flow using radioactive Indium dilution in experimental and control groups.
    • Monitoring blood flow changes over time post-PGF2alpha administration.
    Keywords:
    Abortifacient AgentsAbortion, Drug InducedAbortion, InducedBiologyComparative StudiesEndocrine SystemFamily PlanningFertility Control, PostconceptionPhysiologyProstaglandins--pharmacodynamicsResearch MethodologyStudies

    Related Experiment Videos

    Main Results:

    • Utero-placental blood flow decreased significantly in the PGF2alpha-treated group within 5 minutes.
    • This reduction occurred before the development of advanced intrauterine pressure (IUP).
    • Control patients did not exhibit a similar decrease in blood flow.

    Conclusions:

    • Prostaglandin F2alpha (PGF2alpha) administration leads to an early reduction in utero-placental blood flow.
    • Decreased utero-placental blood flow is an initial step in the mechanism of PGF2alpha-induced pregnancy termination.
    • Findings support animal model data suggesting a causal link between reduced blood flow and PGF2alpha efficacy.