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Regiospecific synthesis of 2,3-disubstituted-L-histidines and histamines
S Narayanan1, S Vangapandu, R Jain
1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Punjab, India.
Bioorganic & Medicinal Chemistry Letters
|May 17, 2001
Abstract:
Regiospecific synthesis of 2,3-disubstituted-L-histidines and 2,3-disubstituted histamines starting from L-histidine methyl ester and histamine is reported. The key step involves homolytic free radical alkylation via silver catalyzed oxidative decarboxylation of alkylcarboxylic acids with ammonium persulfate.