Prostaglandin analogues and uterotonic potency: a comparative study of seven compounds

The uterotonic potency of seven prostaglandin analogues has been investigated using the single intravenous injection technique and comparison of threshold uterine contractility achieved during continuous intravenous infusion. The degree and duration of uterine stimulation in response to graded doses of some of the analogues was also evaluated following intra-amniotic, oral and vaginal administration. 17-Phenyl substituted PGE-2 and PGF-2alpha are reported upon for the first time. Among the prostaglandin compounds tested, the free acid of 16, 16-dimethyl PGE-2 not only is the most potent compound but it may also have great potential for clinical application as an easily administered vaginal abortifacient.