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Updated: Aug 6, 2026
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Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
Association between nonbacterial thrombotic endocarditis and hypoxigenic pulmonary diseases
A M Truskinovsky1, G M Hutchins
1Department of Pathology, Johns Hopkins Hospital, Pathology 401, 600 North Wolfe St., Baltimore, MD 21287, USA. atruski@pds.path.jhu.edu
Summary
Hypoxia from lung disease may cause nonbacterial thrombotic endocarditis (NBTE). Patients with NBTE showed more severe lung disease, suggesting hypoxia
Area of Science:
- Cardiovascular Medicine
- Pulmonary Medicine
- Pathology
Background:
- Nonbacterial thrombotic endocarditis (NBTE) is a condition that can arise in patients with hypoxia.
- The link between hypoxia, often caused by lung diseases, and NBTE development requires further investigation.
Purpose of the Study:
- To investigate a potential pathogenetic relationship between hypoxia and the development of NBTE.
- To compare lung pathology and clinical respiratory compromise in patients with and without NBTE.
Main Methods:
- Retrospective review of 50 autopsied patients with NBTE and 50 matched controls.
- Assessment of lung weight and histopathological severity of lung disease.
- Evaluation of clinical respiratory compromise and cancer extent.
Main Results:
- NBTE patients exhibited significantly heavier lungs and more severe pulmonary disease (histologically and clinically).
- No significant difference in cancer extent was found between NBTE and control groups.
- Even after excluding cancer patients, NBTE cases still showed significantly higher lung injury and clinical compromise scores.
Conclusions:
- The findings suggest a possible causal link between hypoxia and NBTE development in some patients.
- Altered coagulation states may be a mechanism through which hypoxia contributes to NBTE.
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There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
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