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The role of orlistat in weight management
1Monash Medical Centre, Melbourne, Victoria.
Australian Family Physician
|May 18, 2001
Abstract
Background:
Most antiobesity drugs act centrally to reduce appetite or increase satiety. Orlistat is the first in a new class of drugs targeted at a single dietary component, in this case dietary fat.
Objective:
To review the clinical actions and efficacy of orlistat and to discuss its place in overall weight management.
Discussion:
Orlistat is best used in long term weight management as an adjunct to dietary modification and increased physical activity. The reduction in fat absorption results in a slow but sustained weight reduction and improved metabolic parameters such as reduced total, and LDL cholesterol. Side effects are minimised by maintaining a low fat diet.