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Detection and discrimination of latent and replicative herpesvirus infection at the single cell level in vivo

L L Decker1, G J Babcock, D A Thorley-Lawson

  • 1Department of Pathology, Harvard Medical School, Boston, MA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|May 19, 2001
PubMed
Abstract

No abstract available in PubMed .

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Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...

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