Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulation of p53 localization.

S H Liang1, M F Clarke

  • 1Department of Biology, The Pennsylvania State University, University Park, USA.

European Journal of Biochemistry
|May 19, 2001
PubMed
Summary

The regulation of p53 protein localization within cells is complex. This review covers key factors influencing p53 transport, including signals, oligomerization, MDM2, and phosphorylation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The social image of traditional Chinese medicine on <i>the</i> <i>People's Daily</i> after the reform and opening-up policy].

Zhonghua yi shi za zhi (Beijing, China : 1980)·2025
Same author

[News report of People's Daily (1949-1979) for TCM practitioners:Changes in the status of TCM groups].

Zhonghua yi shi za zhi (Beijing, China : 1980)·2023
Same author

Erratum: ZnO-based MIS photodetectors.

Sensors and actuators. A, Physical·2022
Same author

Expression and characterization of anticoagulant activity of salivary protein alALP from Asian tiger mosquito Aedes albopictus.

Tropical biomedicine·2021
Same author

Siblings' experiences of growing up with children with autism in Taiwan and the United Kingdom.

Research in developmental disabilities·2018
Same author

[A pilot study to explore a registry method for acute cardiovascular events].

Zhonghua yi xue za zhi·2017

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The tumor suppressor protein p53 plays a critical role in cellular responses to stress.
  • Understanding p53's cellular localization is crucial for its function.
  • Current knowledge regarding the regulation of p53's movement between the nucleus and cytoplasm is incomplete.

Purpose of the Study:

  • To provide an overview of the mechanisms governing p53 nucleocytoplasmic transport.
  • To discuss the molecular players involved in regulating p53 cellular localization.
  • To highlight unanswered questions in the field of p53 trafficking.

Main Methods:

  • Literature review and synthesis of existing research on p53 transport.
  • Analysis of known nuclear import and export signals of p53.
  • Examination of regulatory factors such as oligomerization, MDM2, and phosphorylation.

Main Results:

  • p53 possesses distinct nuclear import and export signals.
  • Oligomerization can inhibit both p53 nuclear import and export.
  • MDM2 binding is a key mediator of p53 nuclear export.
  • Phosphorylation may play a significant role in modulating p53 localization.

Conclusions:

  • Nucleocytoplasmic transport of p53 is a tightly regulated process involving multiple molecular components.
  • Further research is needed to fully elucidate the dynamic regulation of p53 cellular trafficking.
  • Understanding p53 localization is essential for comprehending its tumor-suppressive functions.

Related Experiment Videos