Severe combined immunodeficiency mouse-human skin chimeras: a unique animal model for the study of psoriasis and cutaneous inflammation
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Published on: January 25, 2016
S P Raychaudhuri1, S Dutt, S K Raychaudhuri
1Psoriasis Research Institute, 600 Town & Country Village, Palo Alto, CA 94301, U.S.A. raysiba@aol.com
Abstract:
Elucidation of the molecular and cellular mechanisms responsible for the pathogenesis of psoriasis had been significantly handicapped due to lack of an ideal animal model. To overcome this hurdle several investigators have developed a number of animal models for psoriasis. Recent establishment of the SCID-human skin chimeras with transplanted psoriasis plaques has opened new vistas to study the molecular complexities involved in psoriasis. This model also offers a unique opportunity to investigate various key biological events such as cell proliferation, angiogenesis, homing in of T cells in target tissues, neurogenic inflammation and cytokine/chemokine cascades involved in an inflammatory reaction. The SCID mouse model will be of immense help to target the cellular and molecular events associated with these pathogenic processes and develop novel drugs for psoriasis and other inflammatory diseases. In this article we have reviewed the prospects and the limitations of the SCID mouse model of psoriasis.
Insights
The SCID-human skin chimera model offers a new way to study psoriasis. This animal model helps research the molecular causes of psoriasis and develop new anti-inflammatory drugs.
Area of Science:
- Immunology
- Dermatology
- Pathogenesis of Psoriasis
Background:
- Psoriasis pathogenesis research was limited by the lack of ideal animal models.
- Various animal models have been developed to study psoriasis.
- SCID-human skin chimeras offer a promising new model system.
Purpose of the Study:
- To review the prospects and limitations of the SCID mouse model for studying psoriasis.
- To highlight the utility of this model in investigating key biological events in psoriasis.
- To discuss its potential for developing novel therapeutic drugs.
Main Methods:
- Transplantation of human psoriasis plaques onto SCID mice.
- Utilizing the SCID-human skin chimera model to study psoriasis pathogenesis.
- Reviewing existing literature on the SCID mouse model for psoriasis.
Main Results:
- The SCID-human skin chimera model allows investigation of cell proliferation, angiogenesis, T cell homing, and cytokine/chemokine cascades.
- This model provides insights into the molecular complexities of psoriasis.
- It facilitates targeted research into cellular and molecular events driving psoriasis.
Conclusions:
- The SCID-human skin chimera model represents a significant advancement in psoriasis research.
- This model is valuable for understanding inflammatory reactions and developing new treatments.
- Further research utilizing this model can lead to novel therapeutic strategies for psoriasis and other inflammatory diseases.
