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Updated: Oct 7, 2026

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations
Published on: January 25, 2018
A novel stimulation pattern improves performance during repetitive dynamic contractions
M B Kebaetse1, S C Lee, S A Binder-Macleod
1Interdisciplinary Programs in Biomechanics and Movement Science, University of Delaware, Newark, Delaware, USA.
Abstract:
The purpose of this study was to determine the effect of three different stimulation patterns on repetitive knee movements. Each subject's quadriceps femoris was stimulated with: (1) a constant-frequency train (CFT) with an interpulse interval (IPI) of 50 ms; (2) a variable-frequency train (VFT)-similar to the CFT, except with an initial doublet with an IPI of 5 ms; and (3) a doublet-frequency train (DFT) with multiple doublets (doublet IPI 5 ms) separated by 50 ms, while the muscle was resisted by a load equal to 10% of the muscle's maximum voluntary isometric contraction. The muscle was stimulated while the knee moved through a 50 degrees arc of motion (90 degrees to 40 degrees of flexion). Testing was stopped when the subject failed to reach the target three consecutive times. Results showed that DFTs reached the target (mean +/- SD) 36.4 +/- 14.4 times, followed by VFTs (25.4 +/- 17.9) and CFTs (17.4 +/- 11.9). The DFT was the best pattern for producing shortening contractions. The results suggest that DFTs may have significant benefits during clinical functional electrical stimulation.
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