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Temporal trends in AIDS-related survival
J Baillargeon1, M J Borucki, J Williamson
1Department of Internal Medicine, University of Texas Medical Branch, Galveston, USA. baillargeon@uthsasa.edu
AIDS Patient Care and Stds
|May 22, 2001
Summary
Survival for individuals with AIDS improved over time, even when measured from clinical indicators other than diagnosis. This study confirms improved survival trajectories for HIV-positive patients through the mid-1990s.
Area of Science:
- Immunology
- Epidemiology
- Public Health
Background:
- AIDS-related survival has improved over time.
- Temporal survival studies are often confounded by AIDS diagnosis stage.
- Need for survival analysis using alternative clinical indicators.
Purpose of the Study:
- Assess temporal trends in AIDS-related survival.
- Utilize clinical indicators beyond AIDS diagnosis.
- Evaluate survival patterns from 1987-1996.
Main Methods:
- Proportional hazards analyses.
- Study sample: 2126 adult HIV-positive patients.
- Data collected at a southwestern academic medical center (1987-1996).
Main Results:
- Survival improved linearly over calendar period from various clinical baselines.
- Improved survival observed for first CD4 count, CD4 count ≥200, CD4 count <200.
- Survival improved for diagnoses including Pneumocystis carinii pneumonia, cytomegalovirus, and Mycobacterium avium complex.
Conclusions:
- Previously estimated survival trajectories persist through the mid-1990s.
- Survival trends remain positive even when excluding AIDS diagnosis.
- Findings support improved long-term outcomes for HIV-positive patients.