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A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
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[The recent advances in the study of dendritic cells and induction of donor antigen-specific T cell tolerance]

Y Li1, S Cai, H Bu

  • 1First University Hospital, West China University of Medical Sciences, Chengdu 610041.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|May 23, 2001
PubMed

The induction of donor antigen specific T cell tolerance will be one of the effective treatment for overcoming rejection and improving the alive quality of long-term recipients. It is increasingly noted that dendritic cell may play a two way regulation role in the balance between transplantation rejection and tolerance as the advances of knowledge of dentritic cell maturation stages. This review will focus on the recent advances in the relation between dendritic cell and induction of donor antigen specific tolerance; its mechanism and potential therapeutic application in transplantation.

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