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[Comparative study on the effect of gossypol and T7 on human spermatozoa ATPase activity]
Abstract
Objective:
A comparative study was carried out on the effect of two kinds of male contraceptive drugs, gossypol and the abstract of tripterygium wilfordii T7, on the human spermatozoa ATPase activity.
Methods:
The specific activity of total ATPase and Na-K ATPase of spermatozoa was assayed in this experiment.
Results:
(1) The effect of gossypol on the human spermatozoa ATPase activity is inhibitory and concentration-dependent; and (2) The abstract of tripterygium wilfodii T7 has no effect on the human spermatozoa ATPase activity.
Conclusions:
The antifertility effects of gossypol and T7 are different.