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Related Concept Videos

Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
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Etiology
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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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Topical corticosteroids in nasal polyposis.

L Badia1, V Lund

  • 1Professorial Unit, Institute of Laryngology and Otology, Royal National Throat, Nose and Ear Hospital, London, England.

Drugs
|May 23, 2001
PubMed
Summary
This summary is machine-generated.

Topical corticosteroids are the preferred medical treatment for nasal polyps, effectively reducing polyp size and improving nasal breathing. They also help prevent polyp recurrence after surgery.

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Area of Science:

  • Otolaryngology
  • Allergy and Immunology
  • Pharmacology

Background:

  • Nasal polyps are inflammatory growths, often chronic and difficult to cure.
  • Management involves medical and surgical options, with topical corticosteroids being the primary medical choice.

Purpose of the Study:

  • To review the efficacy of topical corticosteroids in managing nasal polyps.
  • To outline the objectives and mechanisms of corticosteroid treatment for nasal polyps.

Main Methods:

  • Review of randomized, placebo-controlled trials.
  • Analysis of studies on topical corticosteroids like beclomethasone dipropionate, fluticasone propionate, and budesonide.

Main Results:

  • Topical corticosteroids reduce polyp size, improve nasal airway, and restore the sense of smell.
  • Specific agents like beclomethasone dipropionate, flunisolide, and budesonide delay polyp recurrence post-surgery.
  • Corticosteroids work by reducing inflammatory cells such as T cells and eosinophils.

Conclusions:

  • Topical corticosteroids are highly effective for small to medium nasal polyps and for maintenance therapy.
  • Systemic corticosteroids or surgery may be needed for large polyps where topical application is difficult.