Targeted AML therapy: new biologic paradigms and therapeutic opportunities

GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia.

Leukemia·2011

Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study.

Leukemia·2010

Relapse of acute promyelocytic leukemia with PML-RARalpha mutant subclones independent of proximate all-trans retinoic acid selection pressure.

Leukemia·2006

Minimal residual disease detection in childhood precursor-B-cell acute lymphoblastic leukemia: relation to other risk factors. A Children's Oncology Group study.

Leukemia·2003

Mevastatin can increase toxicity in primary AMLs exposed to standard therapeutic agents, but statin efficacy is not simply associated with ras hotspot mutations or overexpression.

Leukemia research·2003

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study.

Blood·2001

USP8 controls proteostasis pathways in B cells and multiple myeloma.

Leukemia·2026

The FOLR2-IRF2BP2 axis mediates erythropoiesis impairment by excess folic acid in myelodysplastic neoplasms.

Leukemia·2026

SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome.

Leukemia·2026

Multilineage lymphoid clonal hematopoiesis: a cross-sectional, correlative analysis of plasma cell dyscrasias and large granular lymphocytic leukemia.

Leukemia·2026

Non-invasive multiparametric characterization of essential thrombocythemia, premyelofibrosis, and overt myelofibrosis.

Leukemia·2026

Endoplasmic reticulum stress promotes leukemic plasmacytoid dendritic cell differentiation skewing and immune suppression in acute myeloid leukemia.

Leukemia·2026

Rethinking Disease Progression in Transthyretin Amyloid Cardiomyopathy: Toward Mechanism-Specific Monitoring and Therapeutic Response Assessment.

Journal of the American College of Cardiology·2026

2026 Update on Clinical Trials in β-Thalassemia.

American journal of hematology·2026

Knowledgeable Language Models as Black-Box Optimizers for Personalized Medicine.

... International Conference on Learning Representations·2026

Artificial intelligence in trichology: A systematic review of current applications in diagnosis, severity assessment, and treatment monitoring.

Digital health·2026

Durable LVAD therapy in end-stage methamphetamine-associated heart failure: a case report of the bridge to opportunity and transplant candidacy.

European heart journal. Case reports·2026

Construction and validation of a predictive model for HBsAg loss in chronic hepatitis B patients treated with Peg-IFNα-2b.

Frontiers in cellular and infection microbiology·2026

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Targeted AML therapy: new biologic paradigms and therapeutic opportunities

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GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia.

Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study.

Relapse of acute promyelocytic leukemia with PML-RARalpha mutant subclones independent of proximate all-trans retinoic acid selection pressure.

Minimal residual disease detection in childhood precursor-B-cell acute lymphoblastic leukemia: relation to other risk factors. A Children's Oncology Group study.

Mevastatin can increase toxicity in primary AMLs exposed to standard therapeutic agents, but statin efficacy is not simply associated with ras hotspot mutations or overexpression.

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study.

USP8 controls proteostasis pathways in B cells and multiple myeloma.

The FOLR2-IRF2BP2 axis mediates erythropoiesis impairment by excess folic acid in myelodysplastic neoplasms.

SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome.

Multilineage lymphoid clonal hematopoiesis: a cross-sectional, correlative analysis of plasma cell dyscrasias and large granular lymphocytic leukemia.

Non-invasive multiparametric characterization of essential thrombocythemia, premyelofibrosis, and overt myelofibrosis.

Endoplasmic reticulum stress promotes leukemic plasmacytoid dendritic cell differentiation skewing and immune suppression in acute myeloid leukemia.

Rethinking Disease Progression in Transthyretin Amyloid Cardiomyopathy: Toward Mechanism-Specific Monitoring and Therapeutic Response Assessment.

2026 Update on Clinical Trials in β-Thalassemia.

Knowledgeable Language Models as Black-Box Optimizers for Personalized Medicine.

Artificial intelligence in trichology: A systematic review of current applications in diagnosis, severity assessment, and treatment monitoring.

Durable LVAD therapy in end-stage methamphetamine-associated heart failure: a case report of the bridge to opportunity and transplant candidacy.

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Targeted AML therapy: new biologic paradigms and therapeutic opportunities

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