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Related Experiment Videos

Hyperinsulinemia superimposed on insulin resistance does not elevate blood pressure.

S Verma1, Y M Leung, L Yao

  • 1Faculty of Medicine, University of Calgary, Alberta, Canada.

American Journal of Hypertension
|May 23, 2001
PubMed
Summary

Hyperinsulinemia can increase blood pressure (BP) in lean rats, but not in obese, insulin-resistant rats. This suggests pre-existing insulin resistance prevents hyperinsulinemia-induced hypertension.

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Area of Science:

  • Endocrinology
  • Cardiovascular Physiology
  • Metabolic Syndrome

Background:

  • Hyperinsulinemia and insulin resistance are linked to hypertension.
  • The direct effect of exogenous hyperinsulinemia on blood pressure in insulin-resistant states is unclear.

Purpose of the Study:

  • To investigate if exogenous hyperinsulinemia can elevate blood pressure in insulin-resistant rats.
  • To compare the effects of chronic fructose feeding on blood pressure and vascular reactivity in insulin-resistant and insulin-sensitive rats.

Main Methods:

  • Chronic fructose feeding in insulin-resistant Zucker fatty rats and lean controls.
  • Measurement of plasma insulin levels and blood pressure.
  • Assessment of vascular reactivity to norepinephrine in aortic and mesenteric arteries.

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Main Results:

  • Lean rats showed increased plasma insulin and blood pressure after fructose feeding.
  • Insulin-resistant Zucker fatty rats exhibited exaggerated hyperinsulinemia but remained normotensive.
  • Vascular reactivity was similar between obese and lean rats.

Conclusions:

  • In vivo, hyperinsulinemia-induced hypertension mechanisms are not active in obese Zucker rats with pre-existing insulin resistance.
  • Insulin resistance may protect against hyperinsulinemia-induced increases in blood pressure.