Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer-protective properties of high-selenium broccoli.

J W Finley1, C Ip, D J Lisk

  • 1Grand Forks Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 9034, Grand Forks, North Dakota 58203-9034, USA. jfinley@gfhnrc.ars.usda.gov

Journal of Agricultural and Food Chemistry
|May 23, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic, epigenetic, and electrophysiological markers of serotonergic function and SSRI-related nausea.

Journal of affective disorders·2026
Same author

Hot and cold cognitive disturbances in antidepressant-free patients with major depressive disorder: a NeuroPharm study.

Psychological medicine·2020
Same author

Interaction of selenium deficiency and fat intake in the regulation of enzymes associated with peroxide metabolism.

Biological trace element research·2013
Same author

Selenium-mediated inhibition of mammary carcinogenesis.

Biological trace element research·2013
Same author

Characterization of ANIT-induced toxicity using precision-cut rat and dog liver slices cultured in a dynamic organ roller system.

Toxicologic pathology·2006
Same author

Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells.

Oncogene·2005
Same journal

Simultaneous Monitoring of Isopyrazam Isomer Stereoselectivity in Cucumbers and Tomatoes: A Green Chromatographic Strategy with Environmental Implications.

Journal of agricultural and food chemistry·2026
Same journal

Recent Advances and Prospects of Succinate Dehydrogenase Inhibitor Acaricides.

Journal of agricultural and food chemistry·2026
Same journal

Nitric Oxide Supplementation Can Improve the Phytoremediation Potential of <i>Ricinus communis</i> by Regulating the Antioxidant Functioning, Redox Components, and Metal Accumulation.

Journal of agricultural and food chemistry·2026
Same journal

Design, Synthesis, Acaricidal Activity, Structure-Activity Relationship, and Molecular Docking of Novel Piperidine Amine Derivatives Containing a Pyrimidine Motif.

Journal of agricultural and food chemistry·2026
Same journal

Active Pocket Engineering of d-Tagatose 4-Epimerase for Improved Catalytic Performance and Efficient Cascade Synthesis of d-Tagatose from d-Glucose.

Journal of agricultural and food chemistry·2026
Same journal

A Novel Cold-Adapted and Heat-Resistant Alginate Lyase: Unveiling Its Characteristics and Mechanism of Thermostability.

Journal of agricultural and food chemistry·2026
See all related articles

High-selenium broccoli and its sprouts show cancer-protective effects. These foods significantly reduced mammary and colon cancer incidence in rat studies, demonstrating broader chemopreventive potential.

Area of Science:

  • Nutritional Biochemistry
  • Cancer Prevention
  • Chemoprevention

Background:

  • Selenium (Se) is known for cancer-protective properties, with high-Se garlic reducing mammary tumors and high-Se broccoli reducing colon cancer.
  • The efficacy of high-Se broccoli against mammary cancer and the anticarcinogenic activity of broccoli sprouts remain uninvestigated.
  • Secondary plant compounds in broccoli sprouts are recognized for potential cancer risk reduction.

Purpose of the Study:

  • To investigate the chemopreventive effects of high-selenium (Se) broccoli and high-Se broccoli sprouts against chemically induced mammary and colon cancer.
  • To determine if high-Se broccoli offers protection against mammary cancer, an area not previously studied.
  • To evaluate the anticarcinogenic potential of broccoli sprouts, particularly their high-Se varieties.

Related Experiment Videos

Main Methods:

  • Two experiments were conducted using Sprague-Dawley and Fisher F-344 rats.
  • Rats were fed diets supplemented with high-Se broccoli, high-Se broccoli sprouts, or selenite at varying Se concentrations.
  • Tumor incidence (mammary) and aberrant colon crypts (colon) were quantified to assess cancer protection.

Main Results:

  • Rats fed high-Se broccoli demonstrated significantly fewer chemically induced mammary tumors compared to controls.
  • Feeding with high-Se broccoli florets or sprouts led to significantly fewer aberrant colon crypts.
  • These protective effects were observed when compared to diets supplemented with selenite or low-Se broccoli.

Conclusions:

  • The cancer-protective effect of selenium (Se) present in high-Se broccoli extends to protection against mammary cancer.
  • High-Se broccoli sprouts exhibit significant chemopreventive activity against colon cancer.
  • These findings highlight the potential of high-Se broccoli and its sprouts as dietary strategies for cancer prevention.