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Related Experiment Videos

Type A behavior and coronary atherosclerosis.

B Sparagon1, M Friedman, W S Breall

  • 1Meyer Friedman Institute, UCSF-Mount Zion Medical Center, 1600 Divisadero Street, Box 1608, San Francisco, CA 94143-1608, USA. sparagon@mfisf.com

Atherosclerosis
|May 23, 2001
PubMed
Summary
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Type A behavior may contribute to early coronary atherosclerosis, a key factor in heart disease. This study found coronary calcification in 40% of Type A individuals but none in Type B, suggesting a link.

Area of Science:

  • Cardiology
  • Behavioral Medicine
  • Radiology

Background:

  • Type A behavior is a potential risk factor for coronary heart disease.
  • Premature coronary atherosclerosis is suspected to be involved in this risk.
  • Electron beam computed tomography (EBCT) quantifies coronary artery calcification, reflecting atherosclerosis.

Purpose of the Study:

  • To investigate if Type A behavior is associated with the early development of coronary atherosclerosis.
  • To evaluate the role of premature coronary atherosclerosis in the pathogenesis of Type A behavior-related heart disease risk.

Main Methods:

  • A study involving 35 men without clinical coronary heart disease.
  • Participants were categorized into severe Type A (20 men) and Type B (15 men) behavior groups.

Related Experiment Videos

  • Coronary arteries were assessed using Electron Beam Computed Tomography (EBCT), alongside treadmill electrocardiograms.

    • Main Results:

    • Coronary calcification was detected in 8 of 20 (40%) Type A subjects.
    • No coronary calcification was observed in the Type B subjects (P=0.005).
    • A correlation coefficient of 0.39 (P=0.09) was found between Type A score and coronary calcium score.

    Conclusions:

    • The findings suggest that premature coronary atherosclerosis may be a key mechanism linking Type A behavior to increased coronary heart disease risk.
    • Type A behavior's contribution to heart disease pathophysiology could be mediated by accelerated atherosclerosis development.