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Related Experiment Videos

Modeling transdermal drug release.

Y N Kalia1, R H Guy

  • 1Centre Interuniversitaire de Recherche et d'Enseignement, Universities of Geneva and Lyon, 'Pharmapeptides', Parc d'Affaires International, F-74166, Archamps, France. kalia@pharma1.cur-archamps.fr

Advanced Drug Delivery Reviews
|May 23, 2001
PubMed
Summary
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This review explains how the skin

Area of Science:

  • Dermatology
  • Pharmaceutics
  • Biophysics

Background:

  • The stratum corneum is the skin's primary barrier, characterized by lipids and corneocytes.
  • Its lipophilic nature and tortuosity impede drug entry.
  • Drug formulation complexity varies from simple gels to advanced transdermal patches.

Purpose of the Study:

  • To review theoretical principles of transdermal drug release.
  • To demonstrate the applicability of diffusion models for skin penetration.

Main Methods:

  • Review of theoretical principles for transdermal release.
  • Application of Fick's second law of diffusion models.

Main Results:

  • Simple membrane transport models effectively explain drug release kinetics.

Related Experiment Videos

  • These models account for the stratum corneum's complex barrier properties.

    • Conclusions:

    • Fick's laws provide a robust framework for understanding transdermal drug delivery.
    • Predicting drug permeation through the stratum corneum is achievable with diffusion models.