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Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
Intravitreal clindamycin and dexamethasone for toxoplasmic retinochoroiditis
K Kishore1, M D Conway, G A Peyman
1Louisiana Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans, USA.
Ophthalmic Surgery and Lasers
|May 24, 2001
Summary
Intravitreal injections of clindamycin and dexamethasone offer a new treatment for toxoplasmic retinochoroiditis (TRC). This method effectively improved vision and preserved ocular structures in patients, providing an alternative to systemic therapy.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Pharmacology
Background:
- Toxoplasmic retinochoroiditis (TRC) management can be challenging.
- Systemic therapies may have limitations in terms of cost, tolerance, or efficacy.
- A novel treatment approach is needed for recalcitrant or intolerant cases.
Observation:
- A study involved female patients aged 10-61 years with TRC.
- Four eyes of four patients received intravitreal injections of clindamycin and dexamethasone.
- Follow-up ranged from 11 to 26 months.
Findings:
- Intravitreal clindamycin and dexamethasone injections led to favorable responses within two weeks.
- All patients required 2-4 injections for TRC control, with improved visual acuity.
- Ocular structures, including the disc and macula, were preserved in all treated eyes.
Implications:
- Intravitreal injections of clindamycin and dexamethasone are well-tolerated.
- This method provides an alternative strategy for TRC management.
- It is particularly beneficial for patients intolerant to or unresponsive to systemic therapy.
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