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[Prognostic factors in colorectal neoplasm. Multivariate analysis in 224 patients]
G Bannura1, M A Cumsille, J Contreras
1Servicio y Departamento de Cirugía, Hospital Clínico San Borja Arriarán, Campus Centro, Facultad de Medicina y Escuela de Salud Pública, Universidad de Chile. ghannura@rdc.cl
Revista Medica De Chile
|May 25, 2001
Summary
Prognostic factors like lymph node involvement significantly impact colorectal cancer survival. Accurate staging, including lymph node status, is crucial for treatment decisions and patient follow-up.
Area of Science:
- Oncology
- Surgical Pathology
Context:
- Colorectal carcinoma staging is vital for prognosis and treatment planning.
- Current staging classifications and prognostic factors are not universally standardized.
- Accurate staging aids in determining adjuvant therapy and follow-up strategies.
Purpose:
- To evaluate the prognostic significance of clinical and pathological variables in patients undergoing curative resection for colorectal carcinoma.
- To identify key factors influencing survival in colorectal cancer patients.
Summary:
- A retrospective analysis of 224 colorectal cancer patients (99 male, 125 female) after curative resection was conducted.
- Survival at 60 months was 72%. Significant prognostic factors identified include tumor location, vascular permeation, wall infiltration, and lymph node involvement.
- Cox regression analysis highlighted tumor site (colon vs. rectum), carcinoembryonic antigen levels, vascular permeation, number of involved lymph nodes, and apical lymph node presence as significant prognostic indicators.
Impact:
- This study reinforces the prognostic importance of lymph node status in colorectal cancer.
- Findings support the integration of lymph node involvement into established staging systems like Jass, GITSG, and TNM.
- Improved prognostic accuracy can lead to more personalized treatment and follow-up plans for colorectal cancer patients.