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Related Experiment Videos

Autonomic dysfunction in multiple sclerosis: cervical spinal cord atrophy correlates.

J de Seze1, T Stojkovic, J Y Gauvrit

  • 1Department of Neurology, Hôpital R. Salengro, CHRU de Lille, 59037 Lille, France. j-deseze@chru-lille.fr

Journal of Neurology
|May 26, 2001
PubMed
Summary

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Autonomic dysfunction (AD) is common in multiple sclerosis (MS), affecting 84% of patients. This condition correlates with spinal cord atrophy, indicating axonal loss, particularly in progressive MS forms.

Area of Science:

  • Neurology
  • Neuroimmunology
  • Autonomic Neuroscience

Background:

  • Autonomic dysfunction (AD) is infrequently studied in multiple sclerosis (MS).
  • Previous research has not explored the link between AD and spinal cord lesions in MS.
  • Understanding AD's prevalence and pathophysiology in MS is crucial for patient management.

Purpose of the Study:

  • To determine the frequency of autonomic dysfunction in multiple sclerosis patients.
  • To investigate the correlation between autonomic dysfunction and spinal cord magnetic resonance imaging (MRI) findings.
  • To compare the prevalence of AD across different MS subtypes.

Main Methods:

  • Prospective study of 75 MS patients (relapsing-remitting, secondary progressive, primary progressive).

Related Experiment Videos

  • Autonomic function testing included sympathetic skin response, R-R interval variability, and orthostatic hypotension.
  • Spinal cord MRI assessed demyelinating lesions and atrophy; disability was measured using the Extended Disability Status Scale.

    • Main Results:

    • Clinical and laboratory evidence of AD was found in 84% and 56% of MS patients, respectively.
    • AD was more prevalent in primary progressive MS compared to other forms.
    • AD correlated significantly with spinal cord cross-sectional area reduction (atrophy) but not with demyelinating lesions (hyperintensities).

    Conclusions:

    • Autonomic dysfunction is significantly underestimated in multiple sclerosis, particularly in primary progressive forms.
    • Spinal cord atrophy, indicative of axonal loss, is more strongly associated with AD than demyelinating lesions in MS.
    • Findings suggest AD in MS is linked to neurodegenerative processes rather than solely demyelination.