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New rearranged limonoids from Harrisonia perforata. III
Q Khuong-Huu1, A Chiaroni, C Riche
1Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Journal of Natural Products
|May 26, 2001
Summary
Three new limonoids, haperforins C2, F, and G, were discovered in Harrisonia perforata leaves from Vietnam. Their chemical structures were confirmed using advanced analytical techniques like X-ray diffraction.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Harrisonia perforata is a plant species with potential medicinal properties.
- Limonoids are a class of naturally occurring compounds with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new limonoid compounds from Harrisonia perforata.
- To elucidate the chemical structures of these novel compounds.
Main Methods:
- Isolation of compounds from Harrisonia perforata leaf extract.
- Structure determination using single-crystal X-ray diffraction analysis.
- Analysis of Nuclear Magnetic Resonance (NMR) and mass spectral data.
Main Results:
- Three new limonoids, designated haperforins C2 (1), F (2), and G (3), were successfully isolated.
- The chemical structures of compounds 1-3 were unequivocally determined.
- Comprehensive spectroscopic data (NMR, mass spectrometry) were obtained and reported.
Conclusions:
- The study expands the knowledge of limonoids found in Harrisonia perforata.
- The identified compounds represent novel chemical entities for further investigation.