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The Immune Tolerance Network: tolerance at the crossroads.
1Immune Tolerance Network, University of California, San Francisco, 513 Parnossus Avenue, Box 0540 - HSW Room 1114, San Francisco, CA 94143-0540, USA. jbluest@immunology.uchicago.edu
Summary
Immune tolerance therapies aim to reprogram immune cells, offering potential cures for autoimmune diseases and allergies. The Immune Tolerance Network (ITN) accelerates the development of these groundbreaking treatments.
Area of Science:
- Immunology
- Therapeutics
Background:
- Immune tolerance therapies offer a potential alternative to lifelong immunosuppression for autoimmune diseases.
- Advances in understanding T-cell activation create new opportunities for therapeutic development.
Purpose of the Study:
- To establish the Immune Tolerance Network (ITN) to advance clinical applications of immune tolerance therapies.
- To accelerate the development and clinical testing of novel tolerogenic therapies and bioassays.
Main Methods:
- The ITN utilizes an interactive approach involving 70 multidisciplinary immunologists.
- Investigating innovative therapeutic strategies and bioassays for various immune-related conditions.
Main Results:
- Significant progress has been made in understanding the molecular mechanisms of T-cell recognition and activation.
- New opportunities have emerged for testing tolerance-based approaches in human diseases.
Conclusions:
- The ITN is actively promoting the clinical use of immune tolerance therapies.
- Research focuses on autoimmune diseases, transplantation, asthma, and allergies, funded by NIH and JDFI.