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Updated: Aug 2, 2026

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
Is there a link between cervical inlet patch and Barrett's esophagus?
B Avidan1, A Sonnenberg, G Chejfec
1Department of Veterans Affairs Medical Center, Albuquerque, New Mexico 87108, USA.
The cervical inlet patch (CIP), a type of gastric mucosa in the esophagus, was found in 1.1% of individuals. CIP is linked to hiatal hernia, gastric ulcers, and Barrett's esophagus, suggesting a possible shared origin.
Area of Science:
- Gastroenterology
- Esophageal Diseases
- Epidemiology
Background:
- Heterotopic gastric-type mucosa in the esophagus is known as the cervical inlet patch (CIP).
- CIP appears as red mucosal islands in the upper esophagus.
Purpose of the Study:
- To determine the clinical epidemiology of CIP.
- To investigate the relationship between CIP and Barrett's esophagus.
Main Methods:
- A case-control study compared 53 individuals with CIP to 4882 controls.
- Multivariate logistic regression analyzed predictors of CIP presence.
Main Results:
- The prevalence of CIP was 1.1%.
- CIP was associated with hiatal hernia (OR 2.26), gastric ulcer (OR 2.93), and Barrett's esophagus (OR 4.41).
Conclusions:
- The co-occurrence of CIP and Barrett's esophagus may indicate a common embryonic origin.
- Further research into shared etiologies is warranted.
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