Related Experiment Video

Updated: Feb 12, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

49.0K

Decreased risk for microscopic colitis and inflammatory bowel disease among patients with reflux disease

A Sonnenberg1, K O Turner2, R M Genta2,3

  • 1Division of Gastroenterology, Portland VA Medical Center and Oregon Health & Science University, Portland, OR, USA.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
|April 1, 2018
PubMed
Abstract

Insights

Gastro-oesophageal reflux disease (GERD) shows an inverse relationship with inflammatory bowel diseases like microscopic colitis (MC), ulcerative colitis (UC), and Crohn

Area of Science:

  • Gastroenterology and Epidemiology
  • Inflammatory Bowel Disease (IBD) Research
  • Reflux Esophagitis Studies

Background:

  • Proton pump inhibitors are linked to increased microscopic colitis (MC) risk.
  • In ulcerative colitis (UC) and Crohn's disease (CD) patients, proton pump inhibitors correlate with IBD flares and poorer outcomes.
  • Existing research suggests potential links between GERD and IBD, but large-scale epidemiological data is limited.

Purpose of the Study:

  • To investigate the epidemiological associations between gastro-oesophageal reflux disease (GERD) and MC, UC, or CD.
  • To analyze the impact of various GERD manifestations on the incidence of these inflammatory bowel diseases.
  • To clarify the relationship between GERD and IBD in a large patient cohort.

Main Methods:

  • A case-control study utilized the Miraca Life Sciences Database, a national repository of histopathological records.
  • Evaluated 228,506 subjects undergoing bidirectional endoscopy for associations between GERD indicators (Barrett's metaplasia, erosive esophagitis, clinical diagnosis) and MC, UC, or CD.
  • Multivariate logistic regression analysis adjusted for age, sex, and H. pylori status to calculate odds ratios (ORs) and 95% confidence intervals (CIs).

Main Results:

  • A significant inverse relationship was observed between GERD and all studied forms of inflammatory bowel disease.
  • The inverse association was consistent across microscopic colitis (OR=0.62), ulcerative colitis (OR=0.89), and Crohn's disease (OR=0.76).
  • More pronounced inverse relationships were noted with Barrett's metaplasia or erosive esophagitis compared to a clinical GERD diagnosis.

Conclusions:

  • Gastro-oesophageal reflux disease demonstrates an inverse epidemiological association with microscopic colitis, ulcerative colitis, and Crohn's disease.
  • The findings suggest a potential protective effect of GERD against the development of these IBDs.
  • Further research is warranted to elucidate the underlying mechanisms of this observed inverse relationship.
Keywords:
Helicobacter pyloriCollagenous colitisCrohn's diseaseepidemiologylymphocytic colitisulcerative colitis

More Related Videos

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

8.1K
Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model09:31

Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model

Published on: November 9, 2018

9.2K

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.1K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
639
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
726
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
848
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
1.7K