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Selective breeding of two rat lines differing in sensitivity to GHB and baclofen
G Colombo1, C Lobina, R Agabio
1C.N.R. Center for Neuropharmacology, c/o 'Bernard B. Brodie' Department of Neuroscience, University of Cagliari, SS 554, Km. 4.5, I-09042, Monserrato (CA), Italy. colomb@unica.it
Abstract:
Two Wistar-derived rat lines, one sensitive (GHB-S) and the other resistant (GHB-R) to the anesthetic effect of gamma-hydroxybutyric acid (GHB), have been selectively bred. GHB-S and GHB-R rats were also sensitive and resistant, respectively, to the anesthetic effect of baclofen, the prototype GABA(B) receptor agonist, suggesting that they may be useful to elucidate not only the role of endogenous GHB but also that of GABA(B) receptors in sleep and anesthesia.
