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Cell contact dependent extended release of adenovirus by microparticles in vitro
H M Cavanagh1, D Dingwall, J Steel
1School of Biomedical Sciences, Charles Sturt University, Locked Bag 588, NSW 2678, Wagga Wagga, Australia. hcavanagh@csu.edu.au
Journal of Virological Methods
|May 30, 2001
Abstract:
Adenoviral vectors remain one of the most promising methods of gene delivery but are plagued by several inherent problems including immune inactivation and transient expression. This paper reports a novel microparticle-based delivery system for adenovirus that allows high uptake of virus, stable complex formation and extended release. In addition, this microparticle/adenovirus complex has been demonstrated to only release virus upon cell contact. The significant clinical implications of this delivery system are discussed.