Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitochondria make a come back.

I E Scheffler1

  • 1Division of Biology, University of California San Diego, La Jolla, CA 92093-0322, USA. ischeffler@ucsd.edu

Advanced Drug Delivery Reviews
|May 30, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II.

Oncogene·2008
Same author

Investigations of the potential effects of phosphorylation of the MWFE and ESSS subunits on complex I activity and assembly.

The international journal of biochemistry & cell biology·2007
Same author

A century of mitochondrial research: achievements and perspectives.

Mitochondrion·2005
Same author

Molecular genetics of the mammalian NADH-ubiquinone oxidoreductase.

Journal of bioenergetics and biomembranes·2001
Same author

Combined and individual mitochondrial HSP60 and HSP10 expression in cardiac myocytes protects mitochondrial function and prevents apoptotic cell deaths induced by simulated ischemia-reoxygenation.

Circulation·2001
Same author

Glucose-regulated turnover of mRNA and the influence of poly(A) tail length on half-life.

The Journal of biological chemistry·2000
Same journal

Silicone oil in protein drug products and its implications for formulation stability.

Advanced drug delivery reviews·2026
Same journal

Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD).

Advanced drug delivery reviews·2026
Same journal

Lysosome-targeting degrader delivery system: from formulation design to biomedical applications.

Advanced drug delivery reviews·2026
Same journal

Anti-PEG antibodies in nanomedicine: Mechanisms, risks, and opportunities.

Advanced drug delivery reviews·2026
Same journal

Optimizing macrophage-targeted intracellular delivery systems for safe and effective immunotherapies.

Advanced drug delivery reviews·2026
Same journal

Light-controlled CRISPR-dCas9 epigenome editing: advanced drug-delivery strategies and oncology applications.

Advanced drug delivery reviews·2026
See all related articles

This review summarizes current knowledge of mitochondria, highlighting their crucial roles in cell evolution, function, and disease. Future research should focus on mitochondrial DNA repair, apoptosis, and novel drug targets for mitochondrial disorders.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Mitochondria are vital organelles in eukaryotic cell evolution and function.
  • Their dynamic behavior and integration into cellular activities are key research areas.
  • Understanding mitochondria is crucial for addressing cellular processes and diseases.

Purpose of the Study:

  • To review the current state of knowledge regarding mitochondria.
  • To identify areas for future research in mitochondrial biology.
  • To provide a comprehensive overview of mitochondrial functions and relevance.

Main Methods:

  • Literature review of current research on mitochondria.
  • Analysis of established crystal structures of electron transport chain complexes.

Related Experiment Videos

  • Examination of studies on mitochondrial genome replication, expression, and repair.
  • Review of research on mitochondria's role in apoptosis and disease.

    • Main Results:

    • Crystal structures of major electron transport chain complexes (except complex I) are known, aiding proton pumping mechanism analysis.
    • Significant progress in understanding the mitochondrial genome, its replication, and expression, though repair and segregation require further study.
    • Mitochondria's central role in programmed cell death (apoptosis) and mitochondrial diseases is increasingly understood.
    • Expanding repertoire of drugs targeting mitochondrial biochemical mechanisms.

    Conclusions:

    • Mitochondria are fundamental to eukaryotic life, involved in energy production, cell death, and disease.
    • Continued research is needed to fully elucidate mitochondrial DNA dynamics and repair mechanisms.
    • Advances in understanding mitochondrial roles offer new therapeutic avenues for diseases and drug development.