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Microbial genomes: dealing with diversity.

Y Boucher¹, C L Nesbø, W F Doolittle

¹Canadian Institute for Advanced Research Program in Evolutionary Biology, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia BSH 4H7, Canada.

Current Opinion in Microbiology

|May 30, 2001

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Complete genome sequences reveal significant gene content variation, up to 20%, even within the same prokaryotic species. New approaches are emerging to analyze this microbial genomic diversity.

Area of Science:

Microbial genomics
Prokaryotic genetics
Comparative genomics

Background:

Complete genome sequences are available for closely related prokaryotes, including conspecific strains and congeneric species.
Significant genetic diversity exists within microbial populations, challenging traditional genomic analyses.

Purpose of the Study:

To highlight the substantial gene content variation observed in closely related prokaryotes.
To introduce the development of new conceptual and methodological approaches for analyzing microbial genomic diversity.

Main Methods:

Comparative analysis of complete genome sequences from closely related prokaryotes.
Identification and quantification of gene content differences between strains and species.

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Main Results:

Prokaryotic strains of the same species can exhibit substantial differences in gene content, up to 20%.
This finding underscores the high degree of genomic plasticity within microbial species.

Conclusions:

The significant gene content variation necessitates the development of advanced analytical approaches in microbial genomics.
Emerging conceptual and methodological strategies are poised to transform the field of microbial genomics by addressing this diversity.