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Secretory phospholipase A2 activity correlates with postinjury multiple organ failure
D A Partrick1, E E Moore, C C Silliman
1Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, Denver, CO, USA.
Critical Care Medicine
|May 30, 2001
Summary
Elevated secretory phospholipase A2 (sPLA2) activity in severely injured patients is linked to the development of multiple organ failure (MOF). This finding may help predict MOF risk and guide treatment strategies.
Area of Science:
- Biochemistry
- Immunology
- Trauma Surgery
Background:
- Postinjury multiple organ failure (MOF) is a critical complication often driven by systemic hyperinflammation.
- Secretory phospholipase A2 (sPLA2) generates inflammatory lipid mediators, with its levels correlating to injury severity and mortality.
Purpose of the Study:
- To characterize plasma secretory phospholipase A2 type IIa (sPLA2) activity in severely injured patients.
- To determine if sPLA2 activity correlates with the development of MOF.
Main Methods:
- Seventeen severely injured patients at risk for MOF were monitored.
- Plasma sPLA2 activity was measured on postinjury days 0, 1, 2, 3, and 5.
- sPLA2 activity was correlated with MOF scores.
Main Results:
- Six patients (35%) developed MOF.
- MOF patients exhibited significantly elevated sPLA2 activity from 36 hours postinjury onwards compared to non-MOF patients (p < .05).
- sPLA2 levels in stored blood products were not elevated, ruling them out as a source.
Conclusions:
- Increased plasma sPLA2 activity is associated with the development of postinjury MOF.
- sPLA2 may serve as a biomarker for MOF risk in severely injured patients.