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[Speciation of bioactive Al(III) and VO(IV) complexes in biological systems]
1Szervetlen és Analitikai Kémiai Tanszék, Szegedi Tudományegyetem, 6701 Szeged, Postafiók 440.
Acta Pharmaceutica Hungarica
|May 31, 2001
Abstract:
The speciation of the toxic Al(III) and the beneficial VO(IV) in various biofluids and tissues is discussed in order to describe the solution state of these metal ions in the organism. The possibility and the importance of ternary complex formation with relevant biomolecules is emphasised. The importance of the biospeciation of Al(III) ion in its transport and involvement in neurological disorders, and of insulin mimetic VO(IV) complexes is discussed.