Gas chromatographic studies of phenobarbital and diphenylhydantoin after flash-heater alkylation

The functionally excellent flash-heater methylation, ethylation and butylation techniques have been extended to include the higher alkyl homologs. Phenobarbital and diphenylhydantoin have been alkylated using the tetraalkylammonium hydroxides in which the alkyl group ranges from methyl to hexyl. The gas chromatographic properties of the resulting alkyl derivatives have been investigated.