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Sympathetic skin vasoconstriction--further evaluation using laser Doppler techniques.

F Holmlund1, C Freccero, S Bornmyr

  • 1Department of Clinical Physiology, Malmö University Hospital, University of Lund, Malmö, Sweden.

Clinical Physiology (Oxford, England)
|June 15, 2001
PubMed
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This study quantified sympathetic skin vasoconstriction at different skin depths using laser Doppler methods. Results show no significant difference in vasoconstriction between superficial and deep skin compartments.

Area of Science:

  • Physiology
  • Biomedical Engineering

Background:

  • Sympathetic nervous system plays a crucial role in regulating skin blood flow.
  • Understanding vasoconstriction at varying skin depths is important for physiological and clinical applications.

Purpose of the Study:

  • To quantify reflex sympathetic vasoconstriction in skin at different depths.
  • To compare vasoconstriction measurements using laser Doppler perfusion imaging (LDPI) and laser Doppler perfusion monitoring (LDPM) with different probe configurations.

Main Methods:

  • Twenty healthy subjects participated.
  • Finger skin blood flow was measured using LDPI and LDPM.
  • LDPM utilized probes with fiber separations of 0.25 mm (deep) and 0.14 mm (superficial).
  • Reflex vasoconstriction was induced by contralateral hand immersion in cold water (15°C).

Related Experiment Videos

  • A vasoconstriction index (VAC) was calculated based on skin blood flow changes.

    • Main Results:

    • VAC indices for LDPI, LDPM-0.25, and LDPM-0.14 were consistently around 0.60.
    • No significant differences in sympathetic skin vasoconstriction were observed between the probed depths (0.25 mm vs. 0.14 mm).
    • Both blood cell velocity and concentration contributed to perfusion measurements, with velocity dominating the superficial channel (LDPM-0.14).

    Conclusions:

    • Sympathetic skin vasoconstriction is comparable in superficial and deeper skin compartments.
    • Laser Doppler techniques effectively measure sympathetic vasoconstriction at different skin depths.
    • Blood cell velocity and concentration respond proportionally during sympathetic vasoconstriction.