The effect of ruthenium red and NEM on lithium efflux from human erythrocytes

The lithium pump in intact human erythrocytes which has previously been shown to be repressed following lithium carbonate ingestion by manic-depressive subjects is now shown to be inhibited selectively by N-ethylmaleimide and ruthenium red, both of which are known to inhibit the erythrocyte Ca pump. It is proposed that active lithium efflux is linked to the concurrent operation of the calcium pump.