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[Age, environmental factors, and hormonal carcinogenesis]
1N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia 197758.
Voprosy Onkologii
|June 1, 2001
Summary
Hormonal carcinogenesis, a key factor in hormone-dependent tumors, can be promotional or genotoxic. Environmental factors and aging influence its type and mechanisms, impacting cancer prevention strategies.
Area of Science:
- Endocrinology
- Oncology
- Environmental Health
Context:
- Hormonal carcinogenesis is a significant etiological factor in hormone-dependent tumors.
- Understanding the interplay between endocrine disruptors and genetic damage is crucial for cancer research.
- The aging process and environmental exposures can modify hormonal carcinogenesis pathways.
Purpose:
- To discuss modern concepts of hormonal carcinogenesis, differentiating between promotional and genotoxic types.
- To highlight the role of aging and environmental factors in shaping hormonal carcinogenesis.
- To introduce the 'estrogenic effect switching/overtargeting phenomenon' and its implications.
Summary:
- This paper explores hormonal carcinogenesis, classifying it into promotional and genotoxic types.
- It emphasizes how age, aging, and environmental factors influence these types and can lead to the 'estrogenic effect switching/overtargeting phenomenon'.
- This phenomenon involves reduced estrogenic effects and increased DNA-damaging effects from estrogen metabolites.
Impact:
- Findings suggest that hormonal carcinogenesis mechanisms and conditions favoring tumor development are modifiable by developmental stage and environmental influences.
- This understanding is vital for developing effective oncological disease prevention strategies.
- Highlights the need to consider ontogenesis and environmental factors in cancer prevention.