[Age, environmental factors, and hormonal carcinogenesis]
Related Experiment Video
Updated: Oct 7, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
1N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia 197758.
Abstract:
In this paper modern concepts of hormonal carcinogenesis are discussed. Distinguishing of the latter into 2 principal types (promotional and genotoxic) is supported. The role of age, aging and effect of environmental factors in the choice of hormonal carcinogenesis type (as well as for the creation of "estrogenic effect switching/overtargeting phenomenon") is underlined. Mentioned phenomenon is manifested by the weakening of endocrine (hormonal) effects of estrogens together with intensification of genotoxic (DNA-damaging) effect of their metabolites. Conclusion is made that both the conditions favoring hormone-dependent tumors development and the direct mechanisms of hormonal carcinogenesis may be considerably modulated on different stages of ontogenesis and by the influence of environmental factors that is to be taken into considerations while choosing methods for oncological diseases prevention.
Related Concept Videos
Cancer Prevention
Some...
Mutagenicity and Carcinogenicity
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Mutations
Mutations
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

